N-[叔丁氧羰基]甘氨酰-L-亮氨酸合成路线 （共 9 条）
反应条件
sodium phosphate buffer; lipase N (Amano) in acetone
T=37°C;
参考文献
Gewehr, Markus; Kunz, Horst
Synthesis, 1997 , # 12 p. 1499 - 1510
反应条件
triethylamine in water; acetonitrile
T=25°C; 2 h;
参考文献
Hansen, Finn K.; Ha, Khanh; Todadze, Ekaterina; Lillicotch, Aaron; Frey, Alexander; Katritzky, Alan R.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 7162 - 7167
反应条件
sodium hydroxide in methanol
12 h; Ambient temperature;
参考文献
Nagaraj, R.; Balaram, P.
Tetrahedron, 1981 , vol. 37, p. 1263 - 1270
参考文献
Otsuka Pharmaceutical Co., Ltd.; Otsuka Pharmaceutical Factory, Inc.
Patent: US5162305 A1, 1992 ;
反应条件
phosphate buffer; oxygen; tyrosinase in water; acetonitrile
T=20°C; pH=7.0; 44 h;
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 81 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
2: tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 44 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 88 percent / tyrosinase; phosphate buffer / H2O; acetonitrile / 72 h / 20 °C / pH 7.0
2: 81 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
3: tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 44 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: benzene / 90 - 100 °C
2: ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate, Et3N / CH2Cl2 / 4 h / Ambient temperature
3: 91 percent / aq. sodium phosphate buffer, lipase N (Amano) / acetone / 37 °C
View Scheme
参考文献
Gewehr, Markus; Kunz, Horst
Synthesis, 1997 , # 12 p. 1499 - 1510
反应条件
1: 85 percent / DCC / CH2Cl2 / Ambient temperature
2: 95 percent / 2N NaOH / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Nagaraj, R.; Balaram, P.
Tetrahedron, 1981 , vol. 37, p. 1263 - 1270
