(S)-3-(Boc-氨基)-4-苯基丁酸合成路线 （共 23 条）
反应条件
sodium hydroxide; dihydrogen peroxide in methanol; water 2 h;
参考文献
Tetrahedron Letters, , vol. 40, # 13 p. 2629 - 2632
反应条件
1: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 2: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: 95 percent / CH2Cl2; pyridine / 0 - 20 °C 2: acetonitrile; H2O / 24 h / 20 °C 3: conc. HCl; AcOH / 4 h / Heating 4: 93 percent / K2CO3 / dimethylformamide / 18 h / 20 °C 5: 0.81 g / HSCH2CO2H; DBU / dimethylformamide / 5 h / 20 °C 6: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 7: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: acetonitrile; H2O / 24 h / 20 °C 2: conc. HCl; AcOH / 4 h / Heating 3: 93 percent / K2CO3 / dimethylformamide / 18 h / 20 °C 4: 0.81 g / HSCH2CO2H; DBU / dimethylformamide / 5 h / 20 °C 5: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 6: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: conc. HCl; AcOH / 4 h / Heating 2: 93 percent / K2CO3 / dimethylformamide / 18 h / 20 °C 3: 0.81 g / HSCH2CO2H; DBU / dimethylformamide / 5 h / 20 °C 4: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 5: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: 93 percent / K2CO3 / dimethylformamide / 18 h / 20 °C 2: 0.81 g / HSCH2CO2H; DBU / dimethylformamide / 5 h / 20 °C 3: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 4: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 2: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: 0.81 g / HSCH2CO2H; DBU / dimethylformamide / 5 h / 20 °C 2: 94 percent / Na2CO3 / H2O; dioxane / 16 h / 20 °C 3: 99 percent / aq. LiOH / methanol / 17 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 36 p. 7665 - 7674
反应条件
1: diethyl ether; tetrahydrofuran / 18 h / 20 °C 2: 100 percent / silver benzoate; Et3N / 18 h / 20 °C 3: 19 percent / 10 percent aq. NaOH / methanol / 18 h / 20 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 78, # 6 p. 800 - 808
反应条件
1: 91 percent / methanol / 7 h 2: 92 percent / LiOH; H2O / dioxane / 20 h View Scheme
参考文献
Tetrahedron, , vol. 56, # 40 p. 7947 - 7958
