4-乙基-3-硝基苯甲酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; palladium in methanol
参考文献
LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon
Patent: WO2014/73904 A1, 2014 ;
Location in patent: Paragraph 1161-1164 ;
反应条件
1: H2 / Raney-Ni / ethanol 3: aq. KOH View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 52, p. 597 - 609
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 74 percent / 2,6-lutidine / benzene
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 74 percent / 2,6-lutidine / benzene
3: 85 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 74 percent / 2,6-lutidine / benzene
3: 85 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
4: 55 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
thionyl chloride
T=0 - 50°C; 4 h;
参考文献
QUANTICEL PHARMACEUTICALS, INC; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan
Patent: WO2014/89364 A1, 2014 ;
Location in patent: Paragraph 00687; 00688 ;
反应条件
1.1: potassium permanganate; sodium hydroxide / water / 2.5 h / |Reflux
2.1: acetyl chloride / 0.17 h / 20 °C
2.2: 6 h / |Reflux
View Scheme
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
反应条件
1: sulfuric acid; nitric acid / 2 h / 0 °C
2: hydrogenchloride / 20 h / |Reflux
View Scheme
参考文献
LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon
Patent: WO2014/73904 A1, 2014 ;
