(5-氟-1H-吲唑-3-基)-甲醇合成路线 （共 4 条）
反应条件
manganese(IV) oxide in ethyl acetate T=20°C;
参考文献
EP2565192 A1, ;
Paragraph 0352 ;
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-10 - 20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0351 ;
反应条件
1: sulfuric acid / 3 h / |Reflux
2: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C
View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C
1.2: 1 h / |Cooling with ice
1.3: 20 °C / |Cooling with ice
2.1: sulfuric acid / 3 h / |Reflux
3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C
View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
