5-氯磺酰-2-甲氧基苯甲酸合成路线 (共 9 条)
反应条件
chlorosulfonic acid T=0 - 63°C; 1 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18414 A2, 2004 ;
Location in patent: Page 134 ;
反应条件
chlorosulfonic acid in chloroform; water
参考文献
Science Union et Cie
Patent: US3972994 A1, 1976 ;
反应条件
sodium hydroxide; sodium hydrogencarbonate; sodium sulfite 1) H2O, 75 deg C, 1 h, 2) 105 deg C, 47 h; Yield given. Multistep reaction;
参考文献
Brown, Richard W.
Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4974 - 4976
反应条件
1: tin; aqueous hydrochloric acid 2: aq. NaOH solution 3: potassium carbonate; aqueous potassium permanganate solution View Scheme
参考文献
Shah; Bhatt; Kanga
Journal of the Chemical Society, 1933 , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155
反应条件
ammonia in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
phosphorus; iodine; acetic acid
参考文献
Kawahara
Yakugaku Zasshi, 1957 , vol. 77, p. 963
Chem.Abstr., 1958 , p. 2792
反应条件
1: 94.6 percent / NH3 / tetrahydrofuran / 0.5 h / Ambient temperature
2: 1.) ClCO2Et, Et3N, 2.) Et3N / 1.) acetone, 0 deg C, 0.5 h, 2.) 0 deg C, 0.5 h then r.t., 2.5 h
View Scheme
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
hydrogenchloride; tin
参考文献
Shah; Bhatt; Kanga
Journal of the Chemical Society, 1933 , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155
反应条件
1: tin; aqueous hydrochloric acid
2: aq. NaOH solution
View Scheme
参考文献
Shah; Bhatt; Kanga
Journal of the Chemical Society, 1933 , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1934 , vol. 3/2, p. 155