3-甲氧基-1,3,4-三甲基-2,5-哌嗪二酮合成路线 （共 9 条）
反应条件
1: 3-carboxyl-1,3,4-trimethylpiperazine-2,5-dione With [bis(acetoxy)iodo]benzene; iodine in dichloromethane
0.166667 h;
2: methanol in dichloromethane
16 h;
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: TFA / CHCl3 / 16 h / 20 °C
2.1: 4.59 g / toluene / 24 h / Heating
3.1: 89 percent / K2CO3 / acetone / 48 h / Heating
4.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C
5.1: 100 percent / H2 / Pd/C / methanol / 1 h
6.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
6.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C
2.1: 100 percent / H2 / Pd/C / methanol / 1 h
3.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
3.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: 100 percent / H2 / Pd/C / methanol / 1 h
2.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
2.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: 79 percent / 16 h / 180 °C
2.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C
3.1: 100 percent / H2 / Pd/C / methanol / 1 h
4.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
4.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: H2 / Pd/C / methanol / 16 h
2.1: 1.99 g / toluene / 48 h / Heating
3.1: 79 percent / 16 h / 180 °C
4.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C
5.1: 100 percent / H2 / Pd/C / methanol / 1 h
6.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
6.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1.1: 89 percent / K2CO3 / acetone / 48 h / Heating
2.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C
3.1: 100 percent / H2 / Pd/C / methanol / 1 h
4.1: I2; diacetoxyiodobenzene / CH2Cl2 / 0.17 h
4.2: 77 percent / CH2Cl2 / 16 h
View Scheme
参考文献
Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739
反应条件
1: 1-ethyl-4-methyl-3,6-dioxo-piperazine-2-carboxylic acid With [bis(acetoxy)iodo]benzene; iodine
2: methanol
参考文献
Chai, Christina L. L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron Letters, 2003 , vol. 44, # 2 p. 263 - 265
反应条件
1: NaH
2: hydrogen / Pd/C
3: 77 percent / PhI(OAc)2; I2
View Scheme
参考文献
Chai, Christina L. L.; Elix, John A.; Huleatt, Paul B.
Tetrahedron Letters, 2003 , vol. 44, # 2 p. 263 - 265
