1: 4-iodobenzoic acid ethyl ester With lithium dineopentylcuprate in tetrahydrofuran T=-30°C; 2 h; 2: cyclohexenon in tetrahydrofuran T=20°C; Michael addition;
参考文献
Piazza, Claudia; Knochel, Paul
Angewandte Chemie - International Edition, 2002 , vol. 41, # 17 p. 3263 - 3265
potassium hydrogensulfate in tetrahydrofuran; water
参考文献
Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.
Patent: US2002/165241 A1, 2002 ;
1: 4-iodobenzoic acid ethyl ester; diethylzinc With t-Bu-N=P[N=P(NMe)3]3 in hexane; N,N-dimethyl-formamide T=20°C; 5 h; 2: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in hexane; N,N-dimethyl-formamide T=20°C; Negishi coupling; 7 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ueno, Masahiro; Wheatley, Andrew E. H.; Kondo, Yoshinori
Chemical Communications, 2006 , # 33 p. 3549 - 3550
1: With copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 3 h; Heating; 2: With potassium hydroxide in isopropyl alcohol 7 h; Heating; Further stages.;
参考文献
Gallardo, Hugo; Cristiano, Rodrigo; Vieira, Andre A.; Neves Filho, Ricardo A. W.; Srivastava, Rajendra M.
Synthesis, 2008 , # 4 p. 605 - 609
