4-溴苯并[b]噻吩-2-羧酸合成路线 （共 9 条）
反应条件
1: With potassium hydroxide in N,N-dimethyl-formamide T=136°C; 1.5 h; 2: With hydrogenchloride; water in N,N-dimethyl-formamide T=20°C; 0.0833333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1724277 A1, 2006 ;
Location in patent: Page/Page column 28-29 ;
反应条件
sulfuric acid in acetic acid reflux, 8h, then room temp.;
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating 3: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp. View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
2: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp. View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl acetamide T=200°C; 1 h; microwave irradiation;
参考文献
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
反应条件
ammonium hydroxide; thionyl chloride 1) benzene, reflux, 2) ether, 30 min; Yield given. Multistep reaction;
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
borane-THF T=60°C; Cooling with ice;
参考文献
Setoh, Masaki; Ishii, Naoki; Kono, Mitsunori; Miyanohana, Yuhei; Shiraishi, Eri; Harasawa, Toshiya; Ota, Hiroyuki; Odani, Tomoyuki; Kanzaki, Naoyuki; Aoyama, Kazunobu; Hamada, Teruki; Kori, Masakuni
Journal of Medicinal Chemistry, 2014 , vol. 57, # 12 p. 5226 - 5237
反应条件
thionyl chloride in benzene Heating;
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
