2,4-二氯-5-嘧啶甲酸乙酯合成路线 （共 16 条）
反应条件
phosphorus; water; hydrogen iodide; acetic acid
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
反应条件
ammonium hydroxide in 1,4-dioxane T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
Location in patent: Paragraph 00667-00669 ;
WO 2013/012915 A1
参考文献
Dornow; Petsch
Justus Liebigs Annalen der Chemie, 1954 , vol. 588, p. 45,56
反应条件
1: NH3 2: NH3 View Scheme
参考文献
Dornow; Petsch
Justus Liebigs Annalen der Chemie, 1954 , vol. 588, p. 45,56
反应条件
1: triethylamine / dichloromethane; tetrahydrofuran / 3 h / -78 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 5 °C
3: manganese(IV) oxide / tetrahydrofuran / 1 h / 40 °C
View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
N-benzyl-N,N,N-triethylammonium chloride in tetrahydrofuran
T=-10°C; 3 h;
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
