triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=50°C; 72 h;
参考文献
Galagher, Peter T.; Hunt, James C. A.; Lightfoot, Andrew P.; Moody, Christopher J.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2633 - 2637
1: 2-hydroxy-1,3-isoindolinedione With sodium hydride in N,N-dimethyl-formamide
Metallation;
2: sec-butyl bromide With sodium iodide in N,N-dimethyl-formamide
T=70°C; Alkylation; 22 h;
参考文献
High; Prior; Bell; Rangachari
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 2 p. 490 - 501
