oxygen; potassium carbonate in dimethyl sulfoxide T=110°C; 72 h;

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / |Inert atmosphere 1.2: 12 h / -78 - 20 °C / |Inert atmosphere 2.1: (Ra)-12-hydroxy-1,10-bis(2,4,6-triisopropylphenyl)-4,5,6,7-tetrahydrodiindeno[1,3,2]dioxaphosphocine 12-oxide / methanol; toluene; pentane / 12 h / 20 °C View Scheme

(i) nBuLi, iPr2NH, THF, hexane, (ii) O2, (iii) /BRN= 605303/; Multistep reaction;

3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) in toluene T=35°C; 25 h; Inert atmosphere; regioselective reaction;

1: 2-(4-fluorophenyl)-acetonitrile With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere;

potassium hydroxide; sodium methylate in water

sodium hydroxide

potassium carbonate T=180°C; 2.75 h;

in methanol 2 h; Ambient temperatureIrradiationphotoinduced decarboxylation;