2-氯乙氧基-2-乙氧基二乙醇合成路线 （共 57 条）
反应条件
1: 91 percent / K2CO3 / dimethylformamide / 10 h / 95 - 100 °C 2: 68 percent / aq. NaOH; (nC4H9)4NI; p-TsCl / toluene / 13 h / 70 - 75 °C View Scheme
参考文献
Bogaschenko, Tatyana; Basok, Stepan; Kulygina, Catherine; Lyapunov, Alexander; Lukyanenko, Nikolay
Synthesis, 2002 , # 15 p. 2266 - 2270
反应条件
1: sodium iodide / acetone / 72 h / Reflux 2: triethylamine / diethyl ether / Cooling with ice View Scheme
参考文献
Chanthad, Chalathorn; Masser, Kevin A.; Xu, Kui; Runt, James; Wang, Qing
Journal of Materials Chemistry, 2012 , vol. 22, # 2 p. 341 - 344
反应条件
1: 85 percent / BF3*OEt2 / CH2Cl2 / 0 °C 2: 96 percent / NaN3 / dimethylformamide / 5 h / 100 °C 3: 90 percent / LiOH / methanol; H2O / Ambient temperature View Scheme
参考文献
Boumrah, Deradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G.
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7735 - 7738
反应条件
1: 85 percent / BF3*OEt2 / CH2Cl2 / 0 °C 2: 96 percent / NaN3 / dimethylformamide / 5 h / 100 °C 3: 90 percent / LiOH / methanol; H2O / Ambient temperature 4: 100 percent / H2 / 10percent Pd/C / ethanol / 5688.6 Torr View Scheme
参考文献
Boumrah, Deradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G.
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7735 - 7738
反应条件
2: 77 percent / m-chloroperoxybenzoic acid / CHCl3 / 2 h / 60 °C View Scheme
参考文献
Keana, John F. W.; Wu, Yexin; Wu, Guanli
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2571 - 2576
反应条件
1: sodium azide; sodium iodide / water / 96 h / 50 °C 2: palladium 10 on activated carbon; hydrogen / ethanol 3: ethanol View Scheme
参考文献
Dakanali, Marianna; Do, Thai H.; Horn, Austin; Chongchivivat, Akaraphon; Jarusreni, Tuptim; Lichlyter, Darcy; Guizzunti, Gianni; Haidekker, Mark A.; Theodorakis, Emmanuel A.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4443 - 4450
反应条件
1: hydrogenchloride / 20 °C 2: sodium hydride / tetrahydrofuran / Reflux 3: hydrogenchloride / methanol; dichloromethane / Reflux 4: sodium hydride / tetrahydrofuran / Reflux 5: hydrogenchloride / methanol; dichloromethane / Reflux View Scheme
参考文献
Kawakami, Kazumitsu; Sei, Yoshihisa; Yamaguchi, Kentaro; Tsuda, Akihiko
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 875 - 881
反应条件
1: sodium azide; sodium iodide / water / 96 h / 50 °C 2: palladium 10 on activated carbon; hydrogen / ethanol 3: ethanol 4: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 4 h 5: sodium hydroxide / water; toluene / 100 °C 6: triethylamine / dichloromethane 7: sodium azide / N,N-dimethyl-formamide / 70 °C 8: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Gerard, Estelle; Meulle, Aline; Feron, Olivier; Marchand-Brynaert, Jacqueline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 586 - 590
反应条件
1: hydrogenchloride / 20 °C 2: sodium hydride / tetrahydrofuran / Reflux 3: hydrogenchloride / methanol; dichloromethane / Reflux View Scheme
参考文献
Kawakami, Kazumitsu; Sei, Yoshihisa; Yamaguchi, Kentaro; Tsuda, Akihiko
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 875 - 881
反应条件
1: 85 percent / BF3*OEt2 / CH2Cl2 / 0 °C 2: 96 percent / NaN3 / dimethylformamide / 5 h / 100 °C View Scheme
参考文献
Boumrah, Deradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G.
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7735 - 7738
