2-氯乙氧基-2-乙氧基二乙醇合成路线 （共 57 条）
反应条件
sodium azide in N,N-dimethyl-formamide
T=0 - 100°C;
参考文献
Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120
反应条件
in N-methyl-acetamide; dichloromethane
参考文献
Novo Nordisk A/S
Patent: US2009/36353 A1, 2009 ;
反应条件
sodium hydroxide in methanol
2 h; Heating;
参考文献
Sokolowski, Adam
Journal of Physical Chemistry, 1989 , vol. 93, # 25 p. 8223 - 8226
反应条件
1: 48.9 percent / NaOMe / butan-1-ol / 55 h / 100 - 110 °C
2: 57.2 percent / SOCl2, pyridine / benzene / 24 h / 70 - 80 °C
View Scheme
参考文献
Shinkai, Seiji; Inuzuka, Kenichi; Miyazaki, Osamu; Manabe, Osamu
Journal of Organic Chemistry, 1984 , vol. 49, # 18 p. 3440 - 3442
反应条件
1: K2CO3 / dimethylformamide / 90 °C
2: Et3N
3: NaI / acetone
View Scheme
参考文献
Benniston, Andrew C.; Gunning, Patrick; Peacock, Robert D.
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 115 - 123
反应条件
1: 87.5 percent / K2CO3 / dimethylformamide / 96 h / 100 °C
2: 98.4 percent / pyridine
3: 45 percent / Na2CO3 / acetonitrile / 72 h / Heating
4: 86.2 percent / LiAlH4 / tetrahydrofuran / 96 h / Heating
View Scheme
参考文献
Quici, Silvio; Manfredi, Amedea; Pozzi, Gianluca; Cavazzini, Marco; Rozzoni, Angela
Tetrahedron, 1999 , vol. 55, # 34 p. 10487 - 10496
反应条件
1.1: 50 percent / sodium thiosulfate / ethanol / Heating
2.1: HCl / H2O / Heating
2.2: O2
View Scheme
参考文献
Asseline; Bonfils; Kurfurst; Chassignol; Roig; Thuong
Tetrahedron, 1992 , vol. 48, # 7 p. 1233 - 1254
参考文献
Aldrich, Jane V.; Kumar, Vivek
Patent: US2003/134989 A1, 2003 ;
反应条件
potassium carbonate in tetrahydrofuran
24 h;
参考文献
DAEGU GYEONGBUK INSTITUTE OF SCIENCE and TECHNOLOGY
Patent: WO2008/75887 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=95 - 100°C; 10 h;
参考文献
Bogaschenko, Tatyana; Basok, Stepan; Kulygina, Catherine; Lyapunov, Alexander; Lukyanenko, Nikolay
Synthesis, 2002 , # 15 p. 2266 - 2270
