N-叔丁氧羰基-L-苯丙氨酸甲酯合成路线 （共 114 条）
反应条件
1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / -15 - 23 °C 3: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 4: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 5: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature 6: 81 percent / pyridinium dichromate / dimethylformamide / 24 h 7: 69 percent / potassium hydrogen carbonate / dimethylformamide / 24 h View Scheme
参考文献
Medina; Moyano; Pericas; Riera
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578
反应条件
1: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / -15 - 23 °C 2: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 3: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 4: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature 5: 81 percent / pyridinium dichromate / dimethylformamide / 24 h 6: 69 percent / potassium hydrogen carbonate / dimethylformamide / 24 h View Scheme
参考文献
Medina; Moyano; Pericas; Riera
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578
反应条件
in diethyl ether T=-10°C; 5 h;
参考文献
Bajgrowicz, J. A.; Hallaoui, A. El; Jacquier, R.; Pigiere, Ch.; Viallefont, Ph.
Tetrahedron Letters, 1984 , vol. 25, # 26 p. 2759 - 2762
反应条件
1: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 2: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature 3: 81 percent / pyridinium dichromate / dimethylformamide / 24 h 4: 69 percent / potassium hydrogen carbonate / dimethylformamide / 24 h View Scheme
参考文献
Medina; Moyano; Pericas; Riera
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578
反应条件
1: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 2: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 3: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature 4: 81 percent / pyridinium dichromate / dimethylformamide / 24 h 5: 69 percent / potassium hydrogen carbonate / dimethylformamide / 24 h View Scheme
参考文献
Medina; Moyano; Pericas; Riera
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578
反应条件
bis(norbornadiene)rhodium(I) tetrafluoroborate; (11bM)-4-((1R,2S)-1-(diphenylphosphino)-3-methoxy-1-phenylprop-2-yloxy)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; hydrogen in tetrahydrofuran T=20°C; P=15001.5 Torr; 12 h; Autoclave; optical yield given as percent ee;
参考文献
Fernandez-Perez, Hector; Donald, Steven M. A.; Munslow, Ian J.; Benet-Buchholz, Jordi; Maseras, Feliu; Vidal-Ferran, Anton
Chemistry - A European Journal, 2010 , vol. 16, # 22 p. 6495 - 6508
反应条件
tris(dibenzylideneacetone)dipalladium (0); tris-(o-tolyl)phosphine; lithium chloride in N,N-dimethyl-formamide T=20°C; cross-coupling; 3 h;
参考文献
Dexter, Charles S.; Jackson, Richard F.W.; Elliott, Jason
Tetrahedron, 2000 , vol. 56, # 26 p. 4539 - 4540
反应条件
potassium carbonate T=20°C; 3 h;
参考文献
Sakaguchi, Kazuhiko; Okada, Takuya; Shinada, Tetsuro; Ohfune, Yasufumi
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 25 - 28
反应条件
N,N,N',N,-tetramethylethylenediamine; PdCl2(Amphos)2; zinc in water T=20°C; Negishi coupling reaction; 16 h; Inert atmosphere;
参考文献
Ross, Andrew J.; Dreiocker, Frank; Schae Fer, Mathias; Oomens, Jos; Meijer, Anthony J.H.M.; Pickup, Barry T.; Jackson, Richard F.W.
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1727 - 1734
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate in 1,4-dioxane T=85°C; Miyaura borylation; 3 h; Inert atmosphere;
参考文献
Meyer, Falco-Magnus; Collins, James C.; Borin, Brendan; Bradow, James; Liras, Spiros; Limberakis, Chris; Mathiowetz, Alan M.; Philippe, Laurence; Price, David; Song, Kun; James, Keith
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3099 - 3114
