5-羟基-1H-吲哚-2-羧酸甲酯合成路线 （共 11 条）
反应条件
1: With sodium hydroxide in methanol T=60°C; 1 h; 2: With hydrogenchloride in methanol; water
参考文献
Choi, Taeyoung; Ma, Eunsook
Molecules, 2010 , vol. 15, # 11 p. 7971 - 7984
反应条件
hydrogenchloride
48 h; Heating / reflux;
参考文献
Hangauer, David G.
Patent: US2008/4241 A1, 2008 ;
Location in patent: Page/Page column 136-138 ;
US 20080004241 A1
反应条件
in methanol; hexane; dichloromethane
T=20°C; 0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
Location in patent: Page/Page column 67 ;
参考文献
Hangauer JR., David G.; El-Araby, Moustafa E.; Milkiewicz, Karen L.
Patent: US2003/166615 A1, 2003 ;
US 20030166615 A1
反应条件
1: sodium / methanol / 15.5 h / -20 - 0 °C
2: anhydrous xylene / 1 h / Reflux
View Scheme
参考文献
Choi, Taeyoung; Ma, Eunsook
Molecules, 2010 , vol. 15, # 11 p. 7971 - 7984
反应条件
in anhydrous xylene
1 h; Reflux;
参考文献
Choi, Taeyoung; Ma, Eunsook
Molecules, 2010 , vol. 15, # 11 p. 7971 - 7984
反应条件
1: sodium ethylate; ethanol
2: potassium ethylate; diethyl ether
3: FeSO4; aqueous NaOH
4: HCl
5: palladium/charcoal; methanol / Hydrogenation
View Scheme
参考文献
Bergel; Morrison
Journal of the Chemical Society, 1943 , p. 49
反应条件
1: potassium ethylate; diethyl ether
2: FeSO4; aqueous NaOH
3: HCl
4: palladium/charcoal; methanol / Hydrogenation
View Scheme
参考文献
Bergel; Morrison
Journal of the Chemical Society, 1943 , p. 49
反应条件
1: HCl
2: palladium/charcoal; methanol / Hydrogenation
View Scheme
参考文献
Bergel; Morrison
Journal of the Chemical Society, 1943 , p. 49
反应条件
1: FeSO4; aqueous NaOH
2: HCl
3: palladium/charcoal; methanol / Hydrogenation
View Scheme
参考文献
Bergel; Morrison
Journal of the Chemical Society, 1943 , p. 49
