1: 51 percent / diethyl ether 3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature View Scheme

pyridine; silica gel 1) 0 deg C to RT, 2) xylene, 50 deg C then reflux, 45 min; Yield given. Multistep reaction;

1: 91 percent / diethyl ether / 10 h / 0 - 20 °C 2: 100 percent / bromotrimethylsilane / CHCl3 / 2 h / Ambient temperature 3: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h 4: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=100&deg;C;&nbsp;2&nbsp;h;&nbsp;&nbsp;Yield given;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: diethyl ether / 1) 0 deg C, 1 h, 2) RT, 3 h<br />2: NaOMe / methanol / 0.5 h / 25 &deg;C<br /> <br /> &nbsp;