L-半胱氨酸盐酸盐无水物合成路线 （共 109 条）
反应条件
(i) BF3-Et2O, AcOH, (ii) aq. NaOAc; Multistep reaction;
参考文献
Zee-Cheng,K.-Y.; Cheng,C.C.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 414 - 418
反应条件
1: With boron trifluoride diethyl etherate in acetic acid
T=40 - 100°C; 0.666667 h;
2: With sodium acetate in ethanol; water
参考文献
DU PREEZ, Jan Gysbert Hermanus; WENTZEL, Mauritz; KNOETZE, Steyn
Patent: WO2012/153253 A2, 2012 ;
Location in patent: Page/Page column 60 ;
反应条件
sodium hydroxide in ethanol; chloroform; water
T=20°C;
参考文献
Enomoto, Hiroshi; Morikawa, Yuko; Miyake, Yurika; Tsuji, Fumio; Mizuchi, Maki; Suhara, Hiroshi; Fujimura, Ken-ichi; Horiuchi, Masato; Ban, Masakazu
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 442 - 446
反应条件
1,4-dioxane; sodium hydroxide
参考文献
Bray et al.
Biochemical Journal, 1958 , vol. 70, p. 570,571
反应条件
sodium hydroxide in ethanol
参考文献
Hoerhammer; Wagner; Seitz; Vejdelek
Die Pharmazie, 1968 , vol. 23, # 8 p. 462 - 467
反应条件
sodium hydroxide in ethanol
参考文献
ZHU, YIZHUN; Wang, Qian; Zhu, Yichun; Mu, Qing
Patent: US2009/36534 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
N,N,N',N'-tetramethylguanidine in tetrahydrofuran
T=50°C; 1 h; Inert atmosphere;
参考文献
Wlostowski, Marek; Czarnocka, Sylwia; MacIejewski, Piotr
Tetrahedron Letters, 2010 , vol. 51, # 46 p. 5977 - 5979
参考文献
Verderame,M.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 312 - 315
反应条件
triethylamine in dichloromethane
参考文献
Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paolo
Heterocycles, 1993 , vol. 36, # 3 p. 473 - 484
