(S)-(+)-2-己醇合成路线 （共 56 条）
反应条件
hydrogen; palladium 10 on activated carbon; N-butylamine in methanol; water T=25°C; 20 h;
参考文献
DAISO CO., LTD.
Patent: EP1582511 A2, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: propyl bromide With methylmagnesium bromide; magnesium in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: (S)-(-)-propylene oxide With copper dilithium tetrachloride in tetrahydrofuran T=-78 - 20°C; 1.5 h; Inert atmosphere; 3: With water; ammonium chloride in tetrahydrofuran Inert atmosphereCooling with ice;
参考文献
Taguri, Tomonori; Yamakawa, Rei; Fujii, Toru; Muraki, Yuta; Ando, Tetsu
Tetrahedron Asymmetry, 2012 , vol. 23, # 11-12 p. 852 - 858
反应条件
dried cells of Geotrichum candidum; nicotinamide adenine dinucleotide; isopropyl alcohol in various solvent(s) T=30°C; pH=7.0; 20 h; Enzymatic reaction;
参考文献
Matsuda, Tomoko; Nakajima, Yuta; Harada, Tadao; Nakamura, Kaoru
Tetrahedron Asymmetry, 2002 , vol. 13, # 9 p. 971 - 974
反应条件
yeast Enzymatic reaction; Conversion of starting material;
参考文献
Council of Scientific and Industrial Research
Patent: US7056540 B2, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran T=25°C; 2 h;
参考文献
Guindon, Yvan; Ogilvie, William W.; Bordeleau, Josee; Cui, Wei Li; Durkin, Kathy; Gorys, Vida; Juteau, Helene; Lemieux, Rene; Liotta, Dennis; Simoneau, Bruno; Yoakim, Christiane
Journal of the American Chemical Society, 2003 , vol. 125, # 2 p. 428 - 436
反应条件
methanol; toluene-4-sulfonic acid in dichloromethane 1 h; Ambient temperature;
参考文献
Noe, Christian R.; Knollmueller, M.; Dungler, K.; Miculka, C.; Gaertner, P.
Monatshefte fuer Chemie, 1991 , vol. 122, # 8 p. 705 - 718
反应条件
methanol; toluene-4-sulfonic acid in dichloromethane 1 h; Ambient temperature;
参考文献
Noe, Christian R.; Knollmueller, M.; Dungler, K.; Miculka, C.; Gaertner, P.
Monatshefte fuer Chemie, 1991 , vol. 122, # 8 p. 705 - 718
反应条件
potassium carbonate in methanol 1 h; Ambient temperature;
参考文献
Di Nunno, Leonardo; Franchini, Carlo; Nacci, Angelo; Scilimati, Antonio; Sinicropi, Maria Stefania
Tetrahedron Asymmetry, 1999 , vol. 10, # 10 p. 1913 - 1926
反应条件
1: With (-)-(S)-[2-(2-methoxynaphthalen-1yl)phenyl]diphenylphosphine; trichlorosilane; bis(η3-allyl-μ-chloropalladium(II)) T=40°C; 24 h; 2: With potassium fluoride; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; 0.333333 h; 3: With dihydrogen peroxide in tetrahydrofuran; methanol T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Heller, Barbara; Gutnov, Andrey; Fischer, Christine; Drexler, Hans-Joachim; Spannenberg, Anke; Redkin, Dmitry; Sundermann, Corinna; Sundermann, Bernd
Chemistry - A European Journal, 2007 , vol. 13, # 4 p. 1117 - 1128
反应条件
1: 1-methyl-1-pentanol With Candida antarctica lipase B in isopropyl alcohol T=30°C; 0.5 h; Enzymatic reaction; 2: vinyl acetate in isopropyl alcohol T=30°C; 0.1 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ema, Tadashi; Ura, Norichika; Yoshii, Masataka; Korenaga, Toshinobu; Sakai, Takashi
Tetrahedron, 2009 , vol. 65, # 46 p. 9583 - 9591
