2-氨基-5-氯苯甲酰胺合成路线 （共 20 条）
反应条件
lithium aluminium tetrahydride in 1,4-dioxane 4 h; Heating;
参考文献
Peters, Jens-Uwe; Luebbers, Thomas; Alanine, Alexander; Kolczewski, Sabine; Blasco, Francesca; Steward, Lucinda
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 256 - 261
反应条件
1: conc. HCl / 20 °C 2: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
参考文献
Mahajan; Mahalakshmi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 5 p. 1299 - 1300
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: 1.) hydroxymethylpolystyrene, triethylamine, DMAP; 2.) camphorsulphonic acid; 3.) Me3SiCl, NaI / 1.) CH2Cl2, 0-25 deg C, 2 h; 2.) dioxan, reflux, 72 h; 3.) MeCN, dioxan, 75 deg C, 18 h 2: aq. HCl / 2 h / Heating View Scheme
参考文献
Cobb, James M.; Fiorini, Maria T.; Goddard, Chris R.; Theoclitou, Maria-Elena; Abell, Chris
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 1045 - 1048
反应条件
[bbim](+)Br(-) T=120°C; 2.5 h;
参考文献
Potewar; Nadaf; Daniel, Thomas; Lahoti; Srinivasan
Synthetic Communications, 2005 , vol. 35, # 2 p. 231 - 241
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene in methanol T=0°C; 1 h;
参考文献
Synthesis, , # 4 p. 541 - 543
反应条件
hydrogenchloride; urea in pyridine; water
参考文献
American Home Products Corporation
Patent: US5187168 A1, 1993 ;
反应条件
in tetrahydrofuran; toluene
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US5436233 A1, 1995 ;
反应条件
potassium carbonate; copper(I) bromide in dimethyl sulfoxide
T=120°C; 24 h;
参考文献
Wei, Haidong; Li, Tianbin; Zhou, Yue; Zhou, Lihong; Zeng, Qingle
Synthesis (Germany), 2013 , vol. 45, # 24 art. no. SS-2013-F0579-OP, p. 3349 - 3354
