4-(2-氯-6-甲基嘧啶-4-基)吗啉合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C;
参考文献
Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Jacobsen, Helmut; Jolidon, Synese; Luebbers, Thomas
Patent: US2009/215759 A1, 2009 ;
Location in patent: Page/Page column 49 ;
反应条件
N-ethyl-N,N-diisopropylamine in ethanol 1.) 0 deg C, 3 h, 2.) 25 deg C, 24 h, 3.) reflux, 1 h;
参考文献
DuPont Pharmaceuticals Company
Patent: US6342503 B1, 2002 ;
Location in patent: Example 4 ;
US 6342503 B1
反应条件
1: 89 percent / Et3N / 3 h / Heating
2: 87 percent / hydrazine hydrate / ethanol / 3 h / 15 - 20 °C
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参考文献
Vainilavichyus, P. I.; Burbulene, M.-M. V.; Rochka, V.-C. M.; Lautsyuvene, N.-D. I.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 595 - 598
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 931 - 934
