DL-4-氯苯丙氨酸乙酯盐酸盐合成路线 （共 8 条）
反应条件
hydrogenchloride T=0°C;
参考文献
Varnavas, Antonio; Lassiani, Lucia; Valenta, Valentina; Mennuni, Laura; Makovec, Francesco; Hadjipavlou-Litina, Dimitra
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 6 p. 563 - 581
反应条件
1: 56 percent / HCl / H2O; dioxane / Heating 2: 93 percent / HCl / 0 °C View Scheme
参考文献
Varnavas, Antonio; Lassiani, Lucia; Valenta, Valentina; Mennuni, Laura; Makovec, Francesco; Hadjipavlou-Litina, Dimitra
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 6 p. 563 - 581
反应条件
hydrogenchloride; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 1.) CH2Cl2, 20 deg C. Var.: 50 percent aq. NaOH instead of KOH; Multistep reaction;
参考文献
Ghosez, Leon; Antoine, Jean-Pierre; Deffense, Etienne; Navarro, Mirtha; Libert, Valery; et al.
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4255 - 4258
反应条件
thionyl chloride 15 h; Heating;
参考文献
Brunner, Henri; Hankofer, Peter; Holzinger, Ulrich; Treittinger, Barbara; Schoenenberger, Helmut
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 35 - 44
反应条件
2: 1.) 10percent aq. NaOH, Tetrabutylammonium hydrogen sulfate 2.) 1N HCl / 1.) CH2Cl2, 13 deg C. Var.: benzyltriethylammonium chloride and 50percent aq. NaOH or solid KOH View Scheme
参考文献
Ghosez, Leon; Antoine, Jean-Pierre; Deffense, Etienne; Navarro, Mirtha; Libert, Valery; et al.
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4255 - 4258
反应条件
hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate 1.) CH2Cl2, 13 deg C. Var.: benzyltriethylammonium chloride and 50percent aq. NaOH or solid KOH; Multistep reaction;
参考文献
Ghosez, Leon; Antoine, Jean-Pierre; Deffense, Etienne; Navarro, Mirtha; Libert, Valery; et al.
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4255 - 4258
反应条件
sodium hydroxide Yield given;
参考文献
Ghosez, Leon; Antoine, Jean-Pierre; Deffense, Etienne; Navarro, Mirtha; Libert, Valery; et al.
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4255 - 4258
反应条件
Yield given. Yields of byproduct given;
参考文献
Brunner, Henri; Hankofer, Peter; Holzinger, Ulrich; Treittinger, Barbara; Schoenenberger, Helmut
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 35 - 44
