1: 3-pentenoic acid With lithium hexamethyldisilazane in tetrahydrofuran
T=0°C; 1.66667 h;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; 1 h;
3: With hydrogenchloride; water in tetrahydrofuran
参考文献
KOSAN BIOSCIENCES, INC.
Patent: WO2008/141130 A1, 2008 ;
Location in patent: Page/Page column 29-30 ;
1: With triethylaluminum in N,N-dimethyl-formamide; toluene
T=20°C; P=760.051 Torr; 39 h;
2: With hydrogenchloride in water; N,N-dimethyl-formamide; toluene
Cooling;
1: With triethylaluminum in tetrahydrofuran; toluene
T=20°C; P=760.051 Torr; 40 h;
2: With hydrogenchloride in tetrahydrofuran; water; toluene
Cooling;
