4-(2-溴乙基)苯甲酸合成路线 （共 14 条）
反应条件
sodium hydroxide; bromine
参考文献
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.
Patent: WO2009/62883 A1, 2009 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium hydroxide; bromine in 1,4-dioxane; water 1) -5 deg C - 0 deg C, 2-3 h, 2) r.t., overnight;
参考文献
Uvarova, L. R.; Burykina, L. K.; Zubareva, M. M.; Polyanskii, I. D.
Journal of Organic Chemistry USSR (English Translation), 1988 , p. 1346 - 1349
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 7 p. 1495 - 1499
反应条件
1: AlCl3 / CS2 2: Br2, NaOH View Scheme
参考文献
Smith,J.H.; Menger,F.M.
Journal of Organic Chemistry, 1969 , vol. 34, p. 77 - 80
反应条件
1: 4-(2-Bromoethyl)benzoic acid With 1-methyl-pyrrolidin-2-one; 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=-78°C; 0.166667 h; Inert atmosphere; 2: n-octylmagnesium chloride With buta-1,3-diene; nickel dichloride in tetrahydrofuran P=760.051 Torr; 1 h; Inert atmosphereCooling with ice;
参考文献
Iwasaki, Takanori; Higashikawa, Kiyokazu; Reddy, Vutukuri P.; Ho, Willbe W. S.; Fujimoto, Yukari; Fukase, Koichi; Terao, Jun; Kuniyasu, Hitoshi; Kambe, Nobuaki
Chemistry - A European Journal, 2013 , vol. 19, # 9 p. 2956 - 2960
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane 0.5 h; Reflux;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP2272835 A1, 2011 ;
Location in patent: Page/Page column 28-29 ;
反应条件
diazomethyl-trimethyl-silane in dichloromethane T=20°C; 2 h;
参考文献
Applied Research Systems ARS Holding N.V.
Patent: WO2005/12232 A2, 2005 ;
Location in patent: Page/Page column 28-29 ;
WO 2005/012232 A2
反应条件
in methanol; toluene T=20°C; 5 h;
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 106 ;
US 20080153812 A1
反应条件
in tetrahydrofuran; acetic acid
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5739141 A1, 1998 ;
反应条件
thionyl chloride in methanol; chloroform
参考文献
Pfizer Inc.
Patent: US5340831 A1, 1994 ;
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
