(S)-2-(6-羟基-2-萘)丙酸合成路线 （共 6 条）
反应条件
1: With hydrogen bromide in water; acetic acid T=150°C; 3 h; 2: With water 0.5 h;
参考文献
Auspex Pharmaceuticals, Inc.
Patent: US2007/276042 A1, 2007 ;
Location in patent: Page/Page column 58 ;
US 20070276042 A1
反应条件
hydrogen bromide in water 10 h; Heating / reflux;
参考文献
BEZWADA BIOMEDICAL, LLC.
Patent: US2010/209469 A1, 2010 ;
反应条件
hydrogenchloride 18 h; Heating;
参考文献
Ferrayoli, Carlos G.; Palacios, Sara M.; Alonso, Ruben A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 12 p. 1635 - 1638
反应条件
1: (i) EtOH, H2SO4, (ii) /BRN= 969135/, NaH, 1,2-dimethoxy-ethane, (iii) KOH, EtOH 2: aq. HBr / acetic acid / Heating View Scheme
参考文献
Harrison; Lewis; Nelson; Rooks; Roszkowski; Tomolonis; Fried
Journal of medicinal chemistry, 1970 , vol. 13, # 2 p. 203 - 205
反应条件
sodium hydroxide in water
参考文献
Zambon S.p.A
Patent: US4642376 A1, 1987 ;
反应条件
potassium hydroxide in dimethyl sulfoxide
T=20°C; 24 h;
参考文献
Gannett, Peter M.; Miller, Laura; Daft, Jonathan; Locuson, Charles; Tracy, Timothy S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 14 p. 1272 - 1275
