(S)-(-)-α-羟基-γ-丁内酯合成路线 (共 23 条)
反应条件
ion exchange in toluene 1 h; Heating;
参考文献
Wuensch, Bernhard; Diekmann, Heike; Hoefner, Georg
Liebigs Annalen der Chemie, 1993 , # 12 p. 1273 - 1278
反应条件
Birman's catalyst; DPHAA; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphere; enantioselective reaction;
参考文献
Nakata, Kenya; Gotoh, Kouya; Ono, Keisuke; Futami, Kengo; Shiina, Isamu
Organic Letters, 2013 , vol. 15, # 6 p. 1170 - 1173
反应条件
Birman's catalyst; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphere; enantioselective reaction;
参考文献
Nakata, Kenya; Gotoh, Kouya; Ono, Keisuke; Futami, Kengo; Shiina, Isamu
Organic Letters, 2013 , vol. 15, # 6 p. 1170 - 1173
反应条件
(S)-(-)-BTM; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; 24 h; Molecular sieveInert atmosphere;
参考文献
Clark, Robert W.; Deaton, T. Maxwell; Zhang, Yan; Moore, Maggie I.; Wiskur, Sheryl L.
Organic Letters, 2013 , vol. 15, # 24 p. 6132 - 6135
反应条件
acetic acid; sodium nitrite in water T=0°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kenne, Lennart; Unger, Per; Wehler, Thomas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1183 - 1186
反应条件
hydrogenchloride; sodium hydroxide 1.) RT, 17 h; Yield given. Multistep reaction;
参考文献
Shiuey; Partridge; Uskokovic
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1040 - 1046
反应条件
dimethylsulfide borane complex in tetrahydrofuran Title compound not separated from byproducts;
参考文献
Lei, Ping-Sheng; Ogawa, Yuji; Kovac, Pavol
Journal of Carbohydrate Chemistry, 1996 , vol. 15, # 4 p. 485 - 500
反应条件
boric acid trimethyl ester; dimethylsulfide borane complex; toluene-4-sulfonic acid 1.) THF, r.t., 24 h, 2.) CH2Cl2, r.t., 24 h; Yield given. Multistep reaction;
参考文献
Schinzer, Dieter; Bauer, Armin; Schieber, Jennifer
Synlett, 1998 , # 8 p. 861 - 864
反应条件
ethanol; sodium ethanolate Title compound not separated from byproducts;
参考文献
Mori, Kenji; Uematsu, Tamon; Yanagi, Kazunori; Minobe, Masao
Tetrahedron, 1985 , vol. 41, # 13 p. 2751 - 2758
参考文献
Bayer Aktiengesellschaft
Patent: US6355848 B1, 2002 ;
Location in patent: Example 2 ;