4-苯甲氧基-2-羟基苯甲醛合成路线 （共 31 条）
反应条件
1: 2,4-dihydroxy-benzaldehyde With sodium hydrogencarbonate in acetonitrile T=20°C; 0.75 h; Inert atmosphere; 2: benzyl bromide in acetonitrile Inert atmosphereReflux;
参考文献
Tanc, Muhammet; Carta, Fabrizio; Bozdag, Murat; Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4502 - 4510
反应条件
magnesium bromide in diethyl ether; benzene 24 h; Heating;
参考文献
Baldwin, Jack E.; Haraldsson, Gudmundur G.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 5 p. 400 - 401
反应条件
sodium hydrogencarbonate; potassium iodide in acetonitrile T=60°C; 12 h; Large scale reaction;
参考文献
Tong, Ling; Xiong, Ruisheng; Jiang, Hong; Jiang, Xiangrui; Sun, Hongbin; Jiang, Hualiang; Shen, Jingshan
Heterocycles, 2010 , vol. 81, # 7 p. 1697 - 1702
反应条件
1: 2,4-dihydroxy-benzaldehyde With sodium hydrogencarbonate; potassium iodide in acetonitrile T=60°C; 2: benzyl chloride in acetonitrile T=82°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 33 ;
反应条件
manganese(IV) oxide in methanol; dichloromethane T=20°C;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/67615 A2, 2007 ;
Location in patent: Page/Page column 112-113 ;
WO 2007/067615 A2
反应条件
hydrogenchloride; potassium fluoride; Hg in hexane; water; ethyl acetate; acetonitrile
参考文献
SmithKline Beecham Corporation
Patent: US5599988 A1, 1997 ;
反应条件
triethylamine; magnesium chloride in tetrahydrofuran Inert atmosphereReflux; regioselective reaction;
参考文献
Akselsen, yvind W.; Skattebol, Lars; Hansen, Trond Vidar
Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6339 - 6341
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US5232948 A1, 1993 ;
US 5232948 A
反应条件
sodium hydrogencarbonate; potassium iodide in acetonitrile 16 h; Heating;
参考文献
Mendelson, Wilford L.; Holmes, Monica; Dougherty, Jack
Synthetic Communications, 1996 , vol. 26, # 3 p. 593 - 601
反应条件
sodium hydrogencarbonate; potassium iodide in acetonitrile 30 h; Reflux;
参考文献
Zhang, Bei; Zhao, Yanfang; Zhai, Xin; Wang, Lihui; Yang, Jingyu; Tan, Zehui; Gong, Ping
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1046 - 1054
