4-苯甲氧基-2-羟基苯甲醛合成路线 （共 31 条）
反应条件
1: K2CO3; acetone 2: sodium ethylate; ethanol 3: sodium acetate / Erhitzen des Reaktionsprodukts unter vermindertem Druck 4: palladium/charcoal; acetic acid / Hydrogenation 5: diethyl ether; zinc chloride; hydrogen chloride / Erwaermen des Reaktionsprodukts mit Wasser 6: aq. NaOH solution / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure 7: copper-powder; quinoline 8: palladium / 170 °C View Scheme
参考文献
Foster et al.
Journal of the Chemical Society, 1948 , p. 2254,2258
反应条件
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 20 °C / Large scale reaction 2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -30 °C 2.2: 2 h / -30 °C 3.1: N,N-diethylaniline / 3 h / 215 °C / Inert atmosphere 4.1: AlCl3, aluminium chloride; N,N-diethylaniline / dichloromethane / -10 - 0 °C 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C 5.2: 16 h / 20 °C View Scheme
参考文献
Tong, Ling; Xiong, Ruisheng; Jiang, Hong; Jiang, Xiangrui; Sun, Hongbin; Jiang, Hualiang; Shen, Jingshan
Heterocycles, 2010 , vol. 81, # 7 p. 1697 - 1702
反应条件
1: ethanol; sodium ethylate / anschliessend Erwaermen mit wss. Kalilauge 3: hydrogen chloride; acetic acid 4: copper-powder; quinoline View Scheme
参考文献
Foster et al.
Journal of the Chemical Society, 1948 , p. 2254,2258
反应条件
1: ethanol; sodium ethylate / anschliessend Erwaermen mit wss. Kalilauge 3: hydrogen chloride; acetic acid View Scheme
参考文献
Foster et al.
Journal of the Chemical Society, 1948 , p. 2254,2258
反应条件
triethylamine; benzylamine in chloroform T=55°C; 9 h;
参考文献
Wei, Jia; Wang, Pengcheng; Jia, Qianfa; Huang, Jiaoyao; Du, Zhiyun; Zhang, Kun; Wang, Jian
European Journal of Organic Chemistry, 2013 , # 21 p. 4499 - 4502
反应条件
1: 1.) ethylmagnesium bromide / 1) THF; 2) THF
2: manganese dioxide / CH2Cl2
3: 1,2-dichloro-benzene / 9 h / Heating
4: sodium acetate / ethanol / 2.5 h / Heating
5: 92 percent / H2 / Pd/C / ethyl acetate / 3 h
6: methanol; diethyl ether
View Scheme
参考文献
Crombie, Leslie; Josephs, Jonathan L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2591 - 2598
反应条件
1: K2CO3; acetone
2: sodium ethylate; ethanol
3: sodium acetate / Erhitzen des Reaktionsprodukts unter vermindertem Druck
4: palladium/charcoal; acetic acid / Hydrogenation
5: diethyl ether; zinc chloride; hydrogen chloride / Erwaermen des Reaktionsprodukts mit Wasser
6: aq. NaOH solution / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure
7: copper-powder; quinoline
View Scheme
参考文献
Foster et al.
Journal of the Chemical Society, 1948 , p. 2254,2258
反应条件
1: K2CO3; acetone
2: sodium ethylate; ethanol
3: palladium/charcoal; acetic acid / Hydrogenation
View Scheme
参考文献
Foster et al.
Journal of the Chemical Society, 1948 , p. 2254,2258
反应条件
1: sodium tetrahydroborate / ethanol / 11 h / 0 - 20 °C
2: potassium carbonate / acetone / Inert atmosphere; Reflux
3: acetonitrile / Inert atmosphere
4: potassium tert-butylate / methanol / Inert atmosphere; Reflux
5: palladium 10 on activated carbon; hydrogen / ethyl acetate / 1800.18 Torr
View Scheme
参考文献
Luniwal, Amarjit; Erhardt, Paul W.
Synlett, 2011 , # 11 p. 1605 - 1607
反应条件
sodium borohydride; acetic acid; lithium diisopropyl amide in tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Khanna, Ish Kumar; Yu, Yi; Devadas, Balekudru; Lu, Hwang-Fun; Chandrakumar, Nizal S.; Huff, Renee M.; Desai, Bipinchandra N.; Nagarajan, Srinivasan Raj
Patent: US2002/72518 A1, 2002 ;
