1-(1H-吡唑并[4,3-b]吡啶-1-基)乙酮合成路线 （共 3 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol T=20°C; 0.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O'YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu
Patent: WO2013/30138 A1, 2013 ;
Location in patent: Page/Page column 253 ;
反应条件
1: in chloroform
T=0 - 20°C;
2: With potassium acetate; isopentyl nitrite in chloroform
Reflux;
参考文献
F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O'YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu
Patent: WO2013/30138 A1, 2013 ;
Location in patent: Page/Page column 253 ;
反应条件
sulfurous acid bis-(3-methyl-butyl) ester; potassium acetate; acetic anhydride in toluene
T=80°C; 2 h;
参考文献
Eisai Co., Ltd.
Patent: EP1510516 A1, 2005 ;
Location in patent: Page/Page column 134-135 ;
