5-甲基-1H-吡唑并[4,3-b]吡啶合成路线 （共 3 条）
反应条件
methanol; potassium carbonate
0.0833333 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BETAGERI, Rajashekhar; COOK, Brian, Nicholas; DISALVO, Darren; HARCKEN, Christian; KUZMICH, Daniel; LIU, Pingrong; LORD, John; MAO, Can; RAZAVI, Hossein
Patent: WO2012/87782 A1, 2012 ;
Location in patent: Page/Page column 57 ;
WO 2012/087782 A1
反应条件
1: triethylamine / dichloromethane / 2 h
2: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 2 h / Reflux
3: potassium carbonate; methanol / 0.08 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BETAGERI, Rajashekhar; COOK, Brian, Nicholas; DISALVO, Darren; HARCKEN, Christian; KUZMICH, Daniel; LIU, Pingrong; LORD, John; MAO, Can; RAZAVI, Hossein
Patent: WO2012/87782 A1, 2012 ;
WO 2012/087782 A1
反应条件
1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 2 h / Reflux
2: potassium carbonate; methanol / 0.08 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BETAGERI, Rajashekhar; COOK, Brian, Nicholas; DISALVO, Darren; HARCKEN, Christian; KUZMICH, Daniel; LIU, Pingrong; LORD, John; MAO, Can; RAZAVI, Hossein
Patent: WO2012/87782 A1, 2012 ;
WO 2012/087782 A1
