2-溴-４-硝基吡啶氮氧化物合成路线 （共 24 条）
反应条件
sulfuric acid; nitric acid T=130°C; 3 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2004/18463 A2, 2004 ;
Location in patent: Page 42 ;
反应条件
1: perbenzoic acid / CHCl3 / 72 h / Ambient temperature 2: 77 percent / 96percent H2SO4, 96percent HNO3 / 3 h / 130 °C View Scheme
参考文献
Effenberger, Franz; Krebs, Andreas; Willrett, Peter
Chemische Berichte, 1992 , vol. 125, # 5 p. 1131 - 1140
反应条件
acetyl-bromide in acetic acid T=130°C; 16 h;
参考文献
Garcia-Lago, Ramon; Alonso-Gomez, Jose-Lorenzo; Sicre, Cristina; Cid, Maria-Magdalena
Heterocycles, 2008 , vol. 75, # 1 p. 57 - 64
反应条件
1: iron-powder; acetic acid 2: ethanolic sodium ethylate / 160 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1951 , vol. 70, p. 591,598
反应条件
phosphorus tribromide in chloroform 1 h; Reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2004/18463 A2, 2004 ;
Location in patent: Page 42 ;
反应条件
iron in acetic acid T=100°C;
参考文献
Heterocycles, , vol. 75, # 1 p. 57 - 64
参考文献
US5929082 A1, ;
US 5929082 A
反应条件
1: FeSO4; concentrated aqueous NH3 2: NaNO2; aqueous H2SO4; CuSO4 / Diazotization.Reagens 4: Kupfer-Pulver View Scheme
参考文献
Talik
Roczniki Chemii, 1957 , vol. 31, p. 569,574
Chem.Abstr., 1958 , p. 5407
反应条件
1: FeSO4; concentrated aqueous NH3 2: sodium nitrite; aqueous sulfuric acid; potassium iodide / Diazotization View Scheme
参考文献
Talik
Roczniki Chemii, 1957 , vol. 31, p. 569,574
Chem.Abstr., 1958 , p. 5407
反应条件
1: FeSO4; concentrated aqueous NH3 2: NaNO2; aqueous H2SO4; CuSO4 / Diazotization.Reagens 4: Kupfer-Pulver 3: aqueous HCl View Scheme
参考文献
Talik
Roczniki Chemii, 1957 , vol. 31, p. 569,574
Chem.Abstr., 1958 , p. 5407
