1,3-二氢-1-(1-甲基乙炔基)-2H-苯并咪唑-2-酮合成路线 （共 22 条）
反应条件
sulfuric acid; sodium ethanolate 1) EtOH, reflux 4 h; 2) r.t., 2 h; Yield given. Multistep reaction;
参考文献
Jilek, Jiri; Holubek, Jiri; Svatek, Emil; Metys, Jan; Frycova, Hana; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 870 - 883
反应条件
1: 95 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C 2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
in N,N-dimethyl-formamide
参考文献
Cereda, Enzo; Maiocchi, Luciano; Brambilla, Alessandro; Giraldo, Ettore; Monferini, Eugenia; Schiavi, Giovanni Battista
Patent: US2003/27823 A1, 2003 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
PFIZER LIMITED
Patent: US2008/103130 A1, 2008 ;
Location in patent: Page/Page column 43 ;
US 20080103130 A1
反应条件
1: 80 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C 2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: NaOEt
2: aq. H2SO4
3: aq. NaOH / 20 °C
View Scheme
参考文献
Dannhardt, Gerd; Kohl, Beate K.
Archiv der Pharmazie, 2000 , vol. 333, # 5 p. 123 - 129
反应条件
1: 95 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: 90 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: 85 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate
15 h; Heating;
参考文献
Diez-Barra, Enrique; Dotor, Julio; De La Hoz, Antonio; Foces-Foces, Concepcion; Enjalbal, Christine; Aubagnac, Jean Louis; Claramunt, Rosa Maria; Elguero, Jose
Tetrahedron, 1997 , vol. 53, # 22 p. 7689 - 7704
