N-(2-甲基-1-苯基丙烷-2-基)甲酰胺合成路线 （共 12 条）
反应条件
1: 13 percent / polyphosphoric acid 2: 52 percent / aq. hydrogen peroxide, sodium tungstate / ethanol View Scheme
参考文献
Kammoun, Majed; Salah, Hassen Ben; Damak, Mohamed
Synthetic Communications, 2011 , vol. 41, # 10 p. 1520 - 1528
参考文献
Moed et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 919,922
反应条件
1: With oxalyl dichloride in dichloromethane
2: With anhydrous iron chloride
3: With methanol; sulfuric acid
参考文献
Kammoun, Majed; Salah, Hassen Ben; Damak, Mohamed
Synthetic Communications, 2011 , vol. 41, # 10 p. 1520 - 1528
反应条件
sulfuric acid in acetic acid
参考文献
Bernotas, Ronald C.; Thomas, Craig E.; Carr, Albert A.; Nieduzak, Thaddeus R.; Adams, Ginette; Ohlweiler, David F.; Hay, David A.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 10 p. 1105 - 1110
反应条件
1: formic acid With acetic anhydride
T=5 - 20°C; 1.5 h;
2: 1,1-dimethyl-2-phenyl-ethylamine T=20°C; 12 h;
参考文献
ASTELLAS PHARMA INC.
Patent: WO2005/110981 A1, 2005 ;
Location in patent: Page/Page column 39 ;
WO 2005/110981 A1
反应条件
sulfuric acid; acetic acid
T=20°C;
参考文献
Kammoun, Majed; Salah, Hassen Ben; Damak, Mohamed
Synthetic Communications, 2011 , vol. 41, # 10 p. 1520 - 1528
反应条件
sulfuric acid
18 h; Ambient temperature;
参考文献
Chen; Goel; Kesten; Knobelsdorf
Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8129 - 8132
反应条件
sulfuric acid; acetic acid
参考文献
Ritter; Kalish
Journal of the American Chemical Society, 1948 , vol. 70, p. 4048
Organic Syntheses, 1964 , vol. 44, p. 44,45
反应条件
sulfuric acid; acetic acid
参考文献
Ritter; Kalish
Journal of the American Chemical Society, 1948 , vol. 70, p. 4048
Organic Syntheses, 1964 , vol. 44, p. 44,45
反应条件
2: 55 percent / conc. sulfuric acid, glacial acetic acid / 1.) 75 deg C, 30 min, 2.) room temerpature, 2 h
View Scheme
参考文献
Gowenlock, Brian G.; King, Boyd; Pfab, Josef; Witanowski, Michal
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 3 p. 483 - 485
