2-溴-1-乙基-4-硝基苯合成路线 （共 7 条）
反应条件
(i) EtNO2, NaOH, EtOH, (ii) aq. HCl; Multistep reaction;
参考文献
Koevendi,A.; Kircz,M.
Chemische Berichte, 1964 , vol. 97, p. 1902 - 1909
反应条件
1.1: Sn; HCl / Heating
2.1: H2SO4; NaNO2 / H2O / 5 °C
2.2: Na2SO4; H2SO4 / H2O / Heating
View Scheme
参考文献
Wagner, Peter J.; Wang, Lingling
Organic Letters, 2006 , vol. 8, # 4 p. 645 - 647
反应条件
sulfuric acid; bromine; silver sulphate in water
T=20°C;
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
Location in patent: Page/Page column 91 ;
反应条件
sulfuric acid; bromine; silver sulphate in water
T=20°C; 2 h;
参考文献
Hadida Ruah, Sara S.; Miller, Mark T.; Bear, Brian; McCartney, Jason; Grootenhuis, Peter D. J.
Patent: US2008/9524 A1, 2008 ;
Location in patent: Page/Page column 407 ;
反应条件
trifluorormethanesulfonic acid in dichloromethane
参考文献
Bernardon, Jean-Michel; Biadatti, Thibaud
Patent: US2003/195259 A1, 2003 ;
US 20030195259 A1
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite
1.) ice bath, 30 min, 2.) reflux, 1 h; Yield given. Multistep reaction;
参考文献
Cai, Sui Xiong; Kher, Sunil M.; Zhou, Zhang-Lin; Ilyin, Victor; Espitia, Stephen A.; Tran, Minhtam; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 730 - 738
反应条件
tin(ll) chloride in ethanol
1 h; Heating;
参考文献
Cai, Sui Xiong; Kher, Sunil M.; Zhou, Zhang-Lin; Ilyin, Victor; Espitia, Stephen A.; Tran, Minhtam; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 730 - 738
