反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
1.2: 4.25 h / 20 °C / Inert atmosphere
1.3: 2 h / 50 °C / Inert atmosphere
2.1: sodium carbonate / dichloromethane; water
2.2: 18 h / 70 °C / Inert atmosphere
3.1: pyridine / 3.25 h / -15 - 5 °C / Inert atmosphere
4.1: potassium carbonate / acetonitrile / 3.5 h / 80 °C / Inert atmosphere
5.1: potassium hydroxide / 3-methyl pentan-3-ol / 18 h / 120 °C / Inert atmosphere
6.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Dillon, Barry R.; Roberts, Dannielle F.; Entwistle, David A.; Glossop, Paul A.; Knight, Craig J.; Laity, Daniel A.; James, Kim; Praquin, Celine F.; Strang, Ross S.; Watson, Christine A. L.
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 195 - 203