5-硝基-2-(4-哌啶基)-1H-苯并咪唑合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane
T=25°C;
参考文献
He, Yun; Yang, Jun; Wu, Baogen; Robinson, Dale; Sprankle, Kelly; Kung, Pei-Pei; Lowery, Kristin; Mohan; Hofstadler, Steve; Swayze, Eric E.; Griffey, Rich
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 695 - 699
反应条件
1.1: 4-(dimethylamino)pyridine; EDC / dimethylformamide / 4 h / 25 °C
1.2: 66 percent / aq. NaOH / dimethylformamide / 100 °C
2.1: 95 percent / TFA / CH2Cl2 / 25 °C
View Scheme
参考文献
He, Yun; Yang, Jun; Wu, Baogen; Robinson, Dale; Sprankle, Kelly; Kung, Pei-Pei; Lowery, Kristin; Mohan; Hofstadler, Steve; Swayze, Eric E.; Griffey, Rich
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 695 - 699
反应条件
1.1: 4-(dimethylamino)pyridine; EDC / dimethylformamide / 4 h / 25 °C
1.2: 66 percent / aq. NaOH / dimethylformamide / 100 °C
2.1: 95 percent / TFA / CH2Cl2 / 25 °C
View Scheme
参考文献
He, Yun; Yang, Jun; Wu, Baogen; Robinson, Dale; Sprankle, Kelly; Kung, Pei-Pei; Lowery, Kristin; Mohan; Hofstadler, Steve; Swayze, Eric E.; Griffey, Rich
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 695 - 699
