2-甲基-3-氨基苯甲酸合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; Catalytic hydrogenation;
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C;
参考文献
Hourani, Rami; Zhang, Chen; Van Der Weegen, Rob; Ruiz, Luis; Li, Changyi; Keten, Sinan; Helms, Brett A.; Xu, Ting
Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15296 - 15299
反应条件
1.1: NaNO2; H2SO4 / H2O / 0 °C 1.2: 99 percent / aq. H2SO4 / Heating 2.1: 100 percent / hydrogen chloride / Heating 3.1: 72 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1,2-dichloro-ethane in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
G.D. Searle and Co.
Patent: US6046190 A1, 2000 ;
US 6046190 A
反应条件
1: With sulfuric acid; orthoarsenic acid T=160°C; 5 h; 2: With sodium hydroxide in water T=20°C; pH=~ 6;
参考文献
ALLERGAN, INC.
Patent: WO2008/88937 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium hydroxide in sulfuric acid; glycerol
参考文献
ALLERGAN, INC.
Patent: US2009/286829 A1, 2009 ;
US 20090286829 A1
反应条件
1.1: NaNO2; H+ 1.2: potassium ethyl xanthogenate; aq. Na2CO3 / pH 8 1.3: 14.66 g / aq. NaOH / 20 h / Heating 2.1: 93 percent / H2SO4 / 48 h / Heating View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Christenson, Beritte; Klintenberg, Ann-Charlotte; Lamm, Bo; Faegerhag, Jonas; Gatti, Roberto; Oelwegard-Halvarsson, Maria; Shcherbuchin, Vladimir; Elebring, Thomas; Sjoestroem, Jan-Erik
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4282 - 4299
反应条件
1: With sulfuric acid; sodium nitrite in water T=7°C; 0.5 h; 2: With sulfuric acid; water; urea in water T=90°C;
参考文献
Syntex (U.S.A.) LLC
Patent: US6335/459 B1, 2002 ;
Location in patent: Page column 29 ;
Title/Abstract Full Text Show Details
Syntex (U.S.A.) LLC
Patent: US6335459 B1, 2002 ;
Location in patent: Page column 29 ;
US 6335459 B1
反应条件
hydrogenchloride; sulfuric acid; urea; sodium nitrite in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
G. D. Searle and Co.
Patent: US6143747 A1, 2000 ;
US 6143747 A
反应条件
1.1: aq. NaNO2; H2SO4 / 1 h / 55 °C 1.2: aq. NaOH 2.1: 53.4 percent / 55 - 65 °C View Scheme
参考文献
Rohm and Haas Company
Patent: US5530028 A1, 1996 ;
