反应条件
1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol / 2 h / |Reflux; |Inert atmosphere
2: hydrogenchloride / acetone; water / 6 h / 20 °C
View Scheme
参考文献
Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555