1,3,4,5,6,7,8-七氟-2-萘醛合成路线 （共 7 条）
反应条件
n-butyllithium in hexane
T=-70°C; 4.5 h;
参考文献
Brooke, Gerald M.; Mawson, Simon D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1919 - 1923
反应条件
in dimethyl sulfoxide
T=-70°C; 4 h;
参考文献
Brooke, Gerald M.; Mawson, Simon D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1919 - 1923
反应条件
1: 34 percent / dimethylsulfoxide / 4 h / -70 °C
2: 50 percent / butyl-Li / hexane / 4.5 h / -70 °C
View Scheme
参考文献
Brooke, Gerald M.; Mawson, Simon D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1919 - 1923
反应条件
1: CuBr2, 48percent HBr / 1 h / Heating
2: 1) Mg, 1,2-dibromoethane / 1) Et2O, 1h, reflux 2) 1h, reflux
View Scheme
参考文献
Brooke, Gerald M.; Meara, Jeremy M.
Journal of Fluorine Chemistry, 1990 , vol. 50, # 2 p. 229 - 242
反应条件
magnesium; ethylene dibromide
1) Et2O, 1h, reflux 2) 1h, reflux; Yield given. Multistep reaction;
参考文献
Brooke, Gerald M.; Meara, Jeremy M.
Journal of Fluorine Chemistry, 1990 , vol. 50, # 2 p. 229 - 242
反应条件
1: Cl2 / Irradiation
2: (i) Mg, Et2O, (ii) /BRN= 2083926/, THF
View Scheme
参考文献
Osina,O.I.; Shteingarts,V.D.
Zhurnal Organicheskoi Khimii, 1974 , vol. 10, p. 329 - 334,329 - 334
反应条件
(i) Mg, Et2O, (ii) /BRN= 2083926/, THF; Multistep reaction;
参考文献
Osina,O.I.; Shteingarts,V.D.
Zhurnal Organicheskoi Khimii, 1974 , vol. 10, p. 329 - 334,329 - 334
