乙基3-(4-甲基苯基)-2-丙炔酸酯合成路线 （共 20 条）
反应条件
1: sodium hydroxide / ethanol; water / 0.5 h / 20 °C
2: copper(l) iodide; potassium carbonate; triphenylphosphine / dimethyl sulfoxide / 24 h / 90 °C / Inert atmosphere
View Scheme
参考文献
Qu, Xiaoming; Li, Tingyi; Sun, Peng; Zhu, Yan; Yang, Hailong; Mao, Jincheng
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6938 - 6942
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in diethyl ether; water
120 h; Yield given;
参考文献
Qu, Xiaoming; Li, Tingyi; Sun, Peng; Zhu, Yan; Yang, Hailong; Mao, Jincheng
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6938 - 6942
反应条件
1: NaOH, benzyltriethylammonium chloride / H2O; diethyl ether / 120 h
2: 1.) aq. NaOH, 2.) SOCl2 / 2) ether, reflux, 6 h
View Scheme
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
反应条件
1: NaOH, benzyltriethylammonium chloride / H2O; diethyl ether / 120 h
2: 1.) aq. NaOH, 2.) SOCl2 / 2) ether, reflux, 6 h
3: 91 percent / Et3N / toluene / 3 h / Ambient temperature
4: 33 percent Spectr. / 1 h / 750 °C / 0 - 0.1 Torr
View Scheme
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
反应条件
1: 4-methyl phenyl acetylene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: chloroformic acid ethyl ester in tetrahydrofuran; hexane
T=20°C; 19 h; Inert atmosphere;
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
C32H28BrFeIN3Pd; potassium acetate; silver(l) oxide in 1,2-dichloro-ethane
T=80°C; 24 h;
参考文献
Li, Hong-Mei; Xu, Chen; Duan, Lu-Meng; Lou, Xin-Hua; Wang, Zhi-Qiang; Li, Zhen; Fan, Yao-Ting
Transition Metal Chemistry, 2013 , vol. 38, # 3 p. 313 - 318
反应条件
palladium 10 on activated carbon; oxygen; tetra-(n-butyl)ammonium iodide in 1,4-dioxane
T=80°C; P=760.051 Torr; 8 h; Autoclave;
参考文献
Gadge, Sandip T.; Bhanage, Bhalchandra M.
Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-D0181-L, p. 981 - 986
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; hexane
T=50°C; 3 h;
参考文献
Sakamoto; Shiga; Yasuhara; Uchiyama; Kondo; Yamanaka
Synthesis, 1992 , # 8 p. 746 - 748
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 2 h; Inert atmosphere; Reagent/catalystSolvent;
参考文献
Aher, Ravindra D.; Gade, Madhuri H.; Reddy, R. Santhosh; Sudalai, Arumugam
Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical and Analytical Chemistry, 2012 , vol. 51, # 9-10 p. 1325 - 1329,5
反应条件
1: 4-methyl-benzaldehyde With TMSC(Li)N2 in tetrahydrofuran; hexane
T=-78 - 20°C; 1.5 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Further stages.;
参考文献
Hari, Yoshiyuki; Date, Koji; Aoyama, Toyohiko
Heterocycles, 2007 , vol. 74, # C p. 545 - 552
