(1,1-二氧化-3-氧代-1,2-苯异噻唑-2(3h)-基)乙酸合成路线 （共 12 条）
反应条件
1: thionyl chloride / CHCl3; dimethylformamide / 12 h / Ambient temperature 2: CHCl3 3: 25 percent / sodium isopropoxide / propan-2-ol / 0.67 h / 140 °C 4: 210 mg / 0.94N NaOH / H2O; methanol / Ambient temperature View Scheme
参考文献
Perillo; Schapira; Lamdan
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 155 - 160
反应条件
dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
参考文献
Miao, Lei; Xu, Liang; Narducy, Kenneth W.; Trudell, Mark L.
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 820 - 822
反应条件
1: 78 percent / thionyl chloride / 2 h / Heating 2: 65 percent / NaN3 / H2O; acetone / 0.5 h 3: 38 percent / AlCl3 / 1 h / 20 °C View Scheme
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 114, # 1-4 p. 129 - 134
反应条件
1: thionyl chloride / CHCl3; dimethylformamide / 12 h / Ambient temperature
2: CHCl3
3: 25 percent / sodium isopropoxide / propan-2-ol / 0.67 h / 140 °C
View Scheme
参考文献
Perillo; Schapira; Lamdan
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 155 - 160
反应条件
hydrogenchloride in water
T=90°C;
参考文献
D'Ascenzio, Melissa; Carradori, Simone; De Monte, Celeste; Secci, Daniela; Ceruso, Mariangela; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1821 - 1831
反应条件
1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 3 h / |Reflux
2: hydrogenchloride / water / 4 h / 100 °C
View Scheme
参考文献
Chiesi Farmaceutici S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Capaldi, Carmelida; Carzaniga, Laura; La Porta, Elena; Guala, Matilde
Patent: US2013/102576 A1, 2013 ;
反应条件
in N,N-dimethyl-formamide
T=100°C; 1 h;
参考文献
Wrobel, Jay; Dietrich, Arlene; Woolson, Shiela A.; Millen, Jane; McCaleb, Michael; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4613 - 4627
反应条件
hydrogenchloride
1 h; Heating;
参考文献
Soubh; Besch; Otto, Hans-Hartwig
Pharmazie, 2002 , vol. 57, # 6 p. 384 - 392
反应条件
in xylene
Alkylation; 6 h; Heating;
参考文献
Arief
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 114, # 1-4 p. 129 - 134
反应条件
hydrogenchloride
T=130 - 140°C;
参考文献
Abe; Yamamoto
Yakugaku Zasshi, 1953 , vol. 73, p. 1322,1325
Chem.Abstr., 1955 , p. 177
