1,3-二甲氧基-5-氟苯合成路线 （共 26 条）
反应条件
1: 1.) lithium / 1.) ether, 2 h
2: decarboxylation
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
boron tribromide in dichloromethane
T=-30 - 25°C;
参考文献
OLEMA PHARMACEUTICALS, INC.; KUSHNER, Peter, J.; MYLES, David, C.; HARMON, Cyrus, L.; GALLAGHER, Leslie, Carol Hodges
Patent: WO2013/90921 A1, 2013 ;
Location in patent: Paragraph 00154 ;
反应条件
1: 1.) lithium / 1.) ether, 2 h
2: Cu-quinoline
3: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
lithium in diethyl ether
0.5 h;
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 1.) lithium / 1.) ether, 2 h
2: Cu-quinoline
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
water in water; acetonitrile
byproducts: OHC6H3(OMe)2-3,5; Irradiation (UV/VIS); H2O/MeCN=2:1, 254 nm UV-lamp, 0.5-2 h; not isolated, detd. by fluoride ion-selective electrode and pH measurement;
参考文献
Zhang, Guangzhong; Wan, Peter
Journal of the Chemical Society, Chemical Communications, 1994 , # 1 p. 19 - 20
