2-(4-氯苯基)-3-氧代丁腈合成路线 （共 5 条）
反应条件
sulfuric acid; water
参考文献
Kuchar; Brunova; Rejholec; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 122 - 136
反应条件
hydrazine hydrate; acetic acid in toluene T=105°C; 14 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 52 ;
US 20120277224 A1
反应条件
pyridine; hydrogenchloride; hydroxylamine
参考文献
Logemann et al.
Chemische Berichte, 1954 , vol. 87, p. 1175,1176
反应条件
sodium
T=80°C; 14 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 52 ;
US 20120277224 A1
反应条件
1: (p-chlorophenyl)acetonitrile With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.166667 h;
2: acetyl chloride in tetrahydrofuran
T=-78°C; Further stages.;
参考文献
Tarnchompoo, Bongkoch; Sirichaiwat, Chawanee; Phupong, Worrapong; Intaraudom, Chakapong; Sirawaraporn, Worachart; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1244 - 1252
