potassium phosphate; palladium diacetate in N,N-dimethyl-formamide T=130°C; Heck reaction; 24 h;

4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=0 - 25°C; 23 h; Inert atmosphere;

1: N-dicyclohexylcarbodiimide / CH2Cl2 2: 18 percent / MgO / Pd(OAc)2 / dimethylformamide / 24 h / 130 °C View Scheme

1: N-dicyclohexylcarbodiimide / CH2Cl2 2: 18 percent / MgO / Pd(OAc)2 / dimethylformamide / 24 h / 130 °C View Scheme

1: 60 percent / N-dicyclohexylcarbodiimide / CH2Cl2 / 2.5 h 2: 60 percent / K3PO4 / Pd(OAc)2 / dimethylformamide / 24 h / 130 °C View Scheme

1.1: water; potassium hydroxide / methanol / 2 h / 100 °C / Inert atmosphere 1.2: 0 °C / pH 1 / Inert atmosphere 2.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 23 h / 0 - 25 °C / Inert atmosphere View Scheme

pyridine; phosphorus trichoride anschliessendes Erhitzen mit Indol-3-yl-essigsaeure;

in 1,4-dioxane 4 h;