十二氢-4H,8H,12H-4a,8a,12alpha-三氮杂苯并菲合成路线 （共 35 条）
反应条件
1: acetone; piperidine hydrochloride
2: aqueous HCl; H2O / in wss.Loesung vom pH 4.6 und Behandeln der Reaktionsloesung mit Picrinsaeure
3: CrO3; aqueous acetic acid
View Scheme
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1948 , vol. 559, p. 1,22, 23
Chemische Berichte, 1951 , vol. 84, p. 690,698
反应条件
1: toluene / 5 h / Heating
2: 81 percent / Et3N / toluene / Heating
3: 65 percent / 1.) BuLi / tetrahydrofuran / 1.) from -78 deg C to room temp.; 2.) from -30 deg C to room temp.
4: 72 percent / diethyl ether / 1.5 h / Irradiation
5: 80 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
View Scheme
参考文献
Couture; Deniau; Grandclaudon; Lebrun
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752
反应条件
triethylamine in tetrahydrofuran
3 h; Reflux;
参考文献
de Almeida, Valderes Moraes; dos Santos, Rosiel Jose; da Silva Goes, Alexandre Jose; de Lima, Jose Gildo; Duarte Correia, Carlos Roque; de Faria, Antonio Rodolfo
Tetrahedron Letters, 2009 , vol. 50, # 6 p. 684 - 687
反应条件
triethylamine in acetonitrile
T=50 - 55°C; 3 h;
参考文献
Fukawa, Hidemichi; Terao, Yoshiyasu; Achiwa, Kazuo; Sehiya, Minoru
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 94 - 99
反应条件
3 A molecular sieve in methanol
91 h; Ambient temperature;
参考文献
Nomura, Yujiro; Bando, Takashi; Takeuchi, Yoshito; Tomoda, Shuji
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3199 - 3200
反应条件
in various solvent(s)
6 h; Heating1.) steam bath, 6 h 2.) 0 deg C;
参考文献
Richards, James C.; Spenser, Ian D.
Tetrahedron, 1983 , vol. 39, # 21 p. 3549 - 3568
反应条件
T=100°C; in wss. Loesung vom pH 4.6;
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1948 , vol. 559, p. 1,22, 23
Chemische Berichte, 1951 , vol. 84, p. 690,698
反应条件
1: toluene / 5 h / Heating
2: 81 percent / Et3N / toluene / Heating
3: 65 percent / 1.) BuLi / tetrahydrofuran / 1.) from -78 deg C to room temp.; 2.) from -30 deg C to room temp.
4: 72 percent / diethyl ether / 1.5 h / Irradiation
View Scheme
参考文献
Couture; Deniau; Grandclaudon; Lebrun
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752
反应条件
triethylamine in acetonitrile
T=-10 - -5°C; 4 h;
参考文献
Fukawa, Hidemichi; Terao, Yoshiyasu; Achiwa, Kazuo; Sehiya, Minoru
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 94 - 99
反应条件
sodium hydroxide; water
bei pH 11.5;
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1959 , vol. 626, p. 123,131
