3-氨基-1,2-二氢-6-氯-1-甲基-4-苯基喹啉-2(1H)-酮合成路线 （共 11 条）
反应条件
sodium hydroxide in acetone
T=0 - 5°C;
参考文献
Asis, Silvia E.; Bruno, Ana M.; Dominici, Diego A.; Bollini, Mariela; Gaozza, Carlos H.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 1 p. 107 - 112
反应条件
sulfuric acid; water
T=140 - 150°C; 0.5 h;
参考文献
Bahr; Usbeck
Pharmazie, 1981 , vol. 36, # 10 p. 668 - 671
反应条件
ammonia in ethanol
T=80°C; 2 h; Further byproducts given;
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4745 - 4761
反应条件
sulfuric acid; water
T=140 - 150°C; 0.5 h;
参考文献
Bahr; Usbeck
Pharmazie, 1981 , vol. 36, # 10 p. 668 - 671
反应条件
potassium hydroxide in methanol
3.75 h; Heating;
参考文献
Gates, Marshall
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1675 - 1681
反应条件
1: 40percent sodium hydroxide / H2O
2: 38 percent / 220 °C / 0.5 Torr
View Scheme
参考文献
Esteve, Marta E.; Gaozza, Carlos H.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1061 - 1063
反应条件
1: 94 percent
2: 40percent sodium hydroxide / H2O
3: 38 percent / 220 °C / 0.5 Torr
View Scheme
参考文献
Esteve, Marta E.; Gaozza, Carlos H.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1061 - 1063
反应条件
1: 92 percent / aq.NaHCO3 / toluene / 2 h / 40 °C
2: NH3 / ethanol / 2 h / 80 °C
View Scheme
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4745 - 4761
反应条件
1: 85 percent / 1) Na/ethanol; 2) glacial acetic acid / ethanol / 2 h / Heating
2: 83 percent / conc. H2SO4/H2O / 0.5 h / 140 - 150 °C
View Scheme
参考文献
Bahr; Usbeck
Pharmazie, 1981 , vol. 36, # 10 p. 668 - 671
反应条件
1: 66 percent / 1) Na/ethanol; 2) glacial acetic acid / ethanol / 2 h / Heating
2: 86 percent / conc. H2SO4/H2O / 0.5 h / 140 - 150 °C
View Scheme
参考文献
Bahr; Usbeck
Pharmazie, 1981 , vol. 36, # 10 p. 668 - 671
