3-氨基-2-环己烯-1-酮合成路线 （共 56 条）
反应条件
in N,N-dimethyl-formamide
T=100 - 150°C; 6 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/60344 A2, 2006 ;
Location in patent: Page/Page column 21 ;
WO 2006/060344 A2
反应条件
in N,N-dimethyl-formamide
T=70 - 80°C; 3 h;
参考文献
Tang, Weijun; Sun, Yawei; Lijin, Xu; Wang, Tianli; Qinghua Fan; Lam, Kim-Hung; Chan, Albert S.C.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 15 p. 3464 - 3471
参考文献
John Wyeth and Brother Limited
Patent: US3998831 A1, 1976 ;
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane
T=80°C; 8 h;
参考文献
Reddy, B. V. Subba; Reddy, M. Ramana; Rao, Y. Gopal; Yadav; Sridhar
Organic Letters, 2013 , vol. 15, # 3 p. 464 - 467
反应条件
potassium carbonate in 1,4-dioxane
7 h; Heating;
参考文献
Nitta; Soeda; Iino
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 932 - 934
反应条件
sodium hydride in toluene
参考文献
Iida, Hideo; Yuasa, Yoshifumi; Kibayashi, Chihiro
Journal of the Chemical Society, Chemical Communications, 1981 , # 3 p. 114 - 115
反应条件
acetic acid in acetonitrile
Cyclization; Heating;
参考文献
Singh, Kamaljit; Singh, Jasbir; Singh, Harjit
Tetrahedron, 1998 , vol. 54, # 5-6 p. 935 - 942
反应条件
1: 69 percent / Ag2O; MgSO4 / CH2Cl2 / 4 h / 20 °C
2: CH2Cl2 / 20 °C
3: aq. HCl / tetrahydrofuran / 20 °C
4: pyridinium chlorochromate; NaOAc / CH2Cl2 / 20 °C
View Scheme
参考文献
Collet, Sylvain C.; Remi, Jean-Francois; Cariou, Claire; Laib, Samia; Guingant, Andre Y.; Quang Vu, Nguyen; Dujardin, Gilles
Tetrahedron Letters, 2004 , vol. 45, # 25 p. 4911 - 4915
反应条件
acetic acid in toluene
Heating / reflux;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87714 A2, 2005 ;
Location in patent: Page/Page column 133-134 ;
WO 2005/087714 A2
反应条件
1: 49 percent / 4 h / 130 °C
2: 88 percent / diphenyl ether / 0.25 h / Heating
3: 90 percent / hydroxylamine hydrochloride, sodium acetate / aq. ethanol / 1 h / Heating
4: 90 percent / ethyl chloroformate, pyridine / CHCl3 / 48 h / Ambient temperature
View Scheme
参考文献
Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Ueno, Kyoji; Kita, Yasuyuki
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 289 - 296
