3-氨基-2-环己烯-1-酮合成路线 （共 56 条）
反应条件
2: hexane
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
pyridine; p-toluenesulfonyl chloride
1. dimethylformamide, < 0 deg C 2. DMF, 2h; Yield given. Multistep reaction;
参考文献
Hoffman, Jacob M.; Phillips, Brian T.; Cochran, David W.
Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 193 - 195
反应条件
in dichloromethane
T=20°C; Michael addition;
参考文献
Valderrama, Jaime A.; Gonzalez, M. Florencia; Colonelli, Pamela; Vasquez, David
Synlett, 2006 , # 17 p. 2777 - 2780
反应条件
in dichloromethane
T=20°C; Michael addition;
参考文献
Valderrama, Jaime A.; Gonzalez, M. Florencia; Colonelli, Pamela; Vasquez, David
Synlett, 2006 , # 17 p. 2777 - 2780
反应条件
magnesium sulfate; silver(l) oxide in dichloromethane
T=20°C; Michael addition; 4 h;
参考文献
Valderrama, Jaime A.; Colonelli, Pamela; Vasquez, David; Gonzalez, M. Florencia; Rodriguez, Jaime A.; Theoduloz, Cristina
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 24 p. 10172 - 10181
反应条件
silver(l) oxide in dichloromethane
参考文献
Valderrama, Jaime A.; Ibacache, Andrea; Rodriguez, Jaime A.; Theoduloz, Cristina; Benites, Julio
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3398 - 3409
反应条件
magnesium sulfate; silver(l) oxide in dichloromethane
T=20°C; Michael addition; 3 h;
参考文献
Valderrama, Jaime A.; Colonelli, Pamela; Vasquez, David; Gonzalez, M. Florencia; Rodriguez, Jaime A.; Theoduloz, Cristina
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 24 p. 10172 - 10181
反应条件
silver(l) oxide in dichloromethane
参考文献
Valderrama, Jaime A.; Ibacache, Andrea; Rodriguez, Jaime A.; Theoduloz, Cristina; Benites, Julio
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3398 - 3409
反应条件
potassium hydroxide in ethanol; toluene
1.5 h; Heating;
参考文献
Reimann; Poschl
Pharmazie, 1995 , vol. 50, # 9 p. 589 - 592
反应条件
1: With acetic acid in methanol
2: With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; palladium on activated charcoal in N,N-dimethyl-formamide
Heating;
参考文献
Pita; Masaguer; Ravina
Tetrahedron Letters, 2000 , vol. 41, # 50 p. 9829 - 9833
