1-溴-2-甲氧基-3-甲基苯合成路线 （共 8 条）
反应条件
sodium hydroxide; borane; dihydrogen peroxide; magnesium 1.) THF, 65 degC; 2.) 25 degC; Yield given. Multistep reaction;
参考文献
Knoelker, Hans-Joachim; Froehner, Wolfgang; Wagner, Alfred
Tetrahedron Letters, 1998 , vol. 39, # 19 p. 2947 - 2950
反应条件
diethyl ether; magnesium anschliessendes Behandeln mit CO2;
参考文献
Holmberg
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 1137,1400
反应条件
ammonia; sodium amide
参考文献
Benkeser; Buting
Journal of the American Chemical Society, 1952 , vol. 74, p. 3011,3012
参考文献
Benkeser; Buting
Journal of the American Chemical Society, 1952 , vol. 74, p. 3011,3012
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-70 - -20°C; 0.5 h;
参考文献
Amgen Inc.
Patent: US2006/199817 A1, 2006 ;
Location in patent: Page/Page column 49 ;
US 20060199817 A1
反应条件
1: 2-bromo-6-methylphenol With sodium hydride in tetrahydrofuran
1 h;
2: dimethyl sulfate in tetrahydrofuran
参考文献
Glaxo Group Limited
Patent: US2009/203657 A1, 2009 ;
Location in patent: Page/Page column 52 ;
US 20090203657 A1
反应条件
potassium carbonate in acetone
Heating / reflux;
参考文献
Amgen Inc.
Patent: US2006/199817 A1, 2006 ;
Location in patent: Page/Page column 49 ;
US 20060199817 A1
反应条件
1: 86 percent / Br2; tBuNH2 / toluene / -78 °C
2: 91 percent / K2CO3 / acetone / Heating
View Scheme
参考文献
Baret, Paul; Beguin, Claude; Gellon, Gisele; Pierre, Jean-Louis; Serratrice, Guy; Thomas, Fabrice; Laulhere, Jean-Pierre; Saint-Aman, Eric
European Journal of Inorganic Chemistry, 2000 , # 6 p. 1219 - 1227
