2,3-二氢-1H-吲哚-5-磺酸酰胺合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; water in methanol T=20 - 80°C; 20 h; Inert atmosphere; 2: With sodium hydroxide in water pH=7 - 8;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
Location in patent: Page/Page column 144 ;
WO 2012/162365 A1
反应条件
ammonia; water in 1,4-dioxane
参考文献
Wyeth
Patent: US2009/48282 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
1.1: triethylamine; ammonia / dichloromethane; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 20 h / 20 - 80 °C / Inert atmosphere 2.2: pH 7 - 8 View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
WO 2012/162365 A1
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,2-dichloro-ethane T=75°C; 2 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.
Patent: WO2012/162365 A1, 2012 ;
Location in patent: Page/Page column 144 ;
WO 2012/162365 A1
