3,4-二甲氧基-3-环丁烯-1,2-二酮合成路线 （共 20 条）
反应条件
trifluoroacetic acid in methanol T=70°C; 5 h; Heating / refluxIndustry scale;
参考文献
SCHERING CORPORATION
Patent: WO2009/5801 A1, 2009 ;
Location in patent: Page/Page column 30-31 ;
反应条件
in methanol T=24°C; Reflux;
参考文献
Mohamed, Mubina; Goncalves, Theo P.; Whitby, Richard J.; Sneddon, Helen F.; Harrowven, David C.
Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13698 - 13705
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; ethanol; water 2: 3,4-dihydroxy-3-cyclobutene-1,2-dione in diethyl ether; ethanol; water T=20°C;
参考文献
Miles, D.Howard; Payne, Matthew
Tetrahedron, 2001 , vol. 57, # 27 p. 5769 - 5772
反应条件
trimethyl orthoformate Reflux;
参考文献
Packard, Emma; Pascoe, David D.; Maddaluno, Jacques; Goncalves, Theo P.; Harrowven, David C.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 13076 - 13079
Angew. Chem., 2013 , vol. 125, # 49 p. 13314 - 13317,4
反应条件
in xylene T=138°C; Yield given;
参考文献
Lee, Kwan Hee; Moore, Harold W.
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 735 - 738
参考文献
Fu, Nanyan; Allen, Annette D.; Kobayashi, Shinjiro; Tidwell, Thomas T.; Vukovic, Sinisa; Matsuoka, Takeshi; Mishima, Masaaki
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1768 - 1773
参考文献
Reed, Michael W.; Pollart, Daniel J.; Perri, Steven T.; Foland, Lafayette D.; Moore, Harold W.
Journal of Organic Chemistry, 1988 , vol. 53, # 11 p. 2477 - 2482
反应条件
trimethyl orthoformate in methanol Reflux;
参考文献
Schaumann, Ernst; Oppermann, Gerrit; Stranberg, Michael; Moore, Harold W.
Australian Journal of Chemistry, 2010 , vol. 63, # 12 p. 1656 - 1664
参考文献
Liu, Hiu; Tomooka, Craig S.; Moore, Harold W.
Synthetic Communications, 1997 , vol. 27, # 12 p. 2177 - 2180
反应条件
in 2,2,4-trimethylpentane T=25°C; Irradiation; Kinetics;
参考文献
Fu, Nanyan; Allen, Annette D.; Kobayashi, Shinjiro; Tidwell, Thomas T.; Vukovic, Sinisa; Matsuoka, Takeshi; Mishima, Masaaki
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1768 - 1773
